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It's just the computer with standard peripherals, monitor speakers, and display monitors. Nothing else within metres of it. At this point though, like I said it's for all intents and purposes inaudible, so I'm considering the issue fixed.

Got the ground lift adapters in today, and they've made a world of difference. I can still here a tiny bit of the squeal if I get close to the speakers while the GPU is going hard, but it's inaudible from my seating position and definitely so while playing back audio - the quality of which doesn't seem to be affected. I'm very happy with my $10.04 solution! Cheers for the advice guys.

Ordered the adapters, will update once I've tested them out. Thanks for the responses.

Desktop (new, AMD 3600 with a <$100 Asus motherboard), the interface is connected directly to the motherboard via usb. Doesn't matter which usb slot I use. I suspect there's a ground issue, but I don't understand how the interface's headphone jack isn't affected. It's like the active monitors are picking up and amplifying interference (mainly GPU & mouse activity) from the PC via the XLR-TRS cables connected to the interface, even when that interface isn't selected as WIndows' primary audio device. How is that possible? Has anyone used a DI box with ground lift (and attenuation) for monitor speakers here? Would that help? Or maybe even just something like these? Relatively inexpensive so considering giving a couple a shot. A lot of options, all cost money, NFI what the exact problem is in the first place.

Thanks for the reply, but unfortunately that didn't appreciably change the situation one way or the other. Still getting squeals and whining when I move the mouse.

Hi I'm getting high pitched pops & clicks, static, and notably when my GPU is active, a loud squeal on my monitors (Yamaha HS80Ms) while connected to my interface (I've tried two I had on hand, a Roland UA-25EX and a Focusrite Scarlett 2i2 - it happens with both but is worse with the Scarlett). Even just moving my mouse results in a whine. I have no problems with the headphone jacks on either; it's just the rear outs hooking into my monitors that appear to be the issue. I'm using XLR to TRS 1/4" (with 1/4" to RCA adapters for the Scarlett,they may be why it's worse on that unit, not sure). All my gear is on the same power hub. Trying to research what the issue may be is doing my head in. There are as many people saying any given solution doesn't work for them as there are people who say it did. Has anyone here been able to successfully work through similar issues and is willing to share or help me debug my problem? Thanks